In the rat hypothalamus and medial peptic region, Modafinil 200 mg lowers -aminobutyric acids but raises glutamate. The most likely cause of these alterations is modification of monoamine systems, such as DA and adrenergic receptors. Micro dialysis shows that catecholamines influence the arousal and wakefulness-promoting effects of Modafinil. Furthermore, DAT-knockout animals do not respond to Modafinil in the extracellular monoamine system. In these animals, Modafinil has also been demonstrated to activate the dopamine transporter rather than the D2 auto receptor in order to provide its stimulating effects.
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